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Epidermoid cyst of the oral and maxillofacial region is a soft tissue cyst lined with keratinized stratified squamous epithelium and most commonly arises in the superficial area of the mouth floor. Uncommonly, the epidermoid cyst may arise deeply in the submandibular region and should be differentially diagnosed with cystic salivary gland tumors, developmental cysts and other cystic lesions. We report a rare case of an epidermoid cyst near the submandibular gland, clinically and radiographically mistaken as a salivary gland tumor.