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Cherubism is a rare familial multilocular cystic disease of the jaws. Cherubism mostly has an autosomal dominant inheritance. This disease mainly occurs in children, has a tendency toward spontaneous remisson after puberty. Clinically, it shows bilateral bone enlargement of the jaws and multilocular cystic lesion on radiograph. Histologically, the lesion shows fibrovascular stroma and osteoblast like multinucleated giant cell. These features are similar to other bone disease such as central giant cell granuloma. So it needs differential diagnosis by clinical, radiological and histophathologic examinations. We report with review of literatures the fifteen years old male patient who had diagnosed as cherubism by clinicoradiological and histopathologic examination results.