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672 2017 41권 5호

이하선에 발생한 세관선종: 증례보고

저자 김도형, 팽준영, 이성탁, 최소영

초록

Canalicular adenoma is an uncommon, benign salivary gland tumor. It has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate. Rarely, canalicular adenoma can involve the major salivary glands, such as the parotid gland. Only a small number of cases of canalicular adenoma of the parotid gland have been reported in the literature. We report a rare case of canalicular adenoma on the left parotid gland of an 81-year-old man, and present a review of the literature.

671 2017 41권 5호

구강 내 누공이 있는 낭성 병소와 제 3대구치의 병적 이동

저자 이은희, 김대훈, 장효원, 박광호, 허종기

초록

There are many case reports about cysts within the bones of the jaws associated with impacted third molars. When osmotic pressure is introduced into a cyst, the cyst expands and displaces the third molar. If continuity of cyst wall is lost, cystic expansion cannot occur, and the cyst cannot displace the third molar. This study analyzed four cases of pathologic migration of the third molar in ruptured cystic lesions that had formed bone tunnels and intraoral fistulas to identify the causes and factors contributing to this migration. Authors hypothesized that closure of fistulas repeated generation of pressure, it may temporarily increase the osmotic pressure within a cyst that has lost its continuity, causing displacement of the third molar. A cyst that has lost its continuity due to fistula formation within the oral cavity can cause ectopic displacement of the adjacent impacted teeth.

670 2017 41권 5호

이소성 다형성 선종: 증례 보고

저자 모하메드 바크리, 예서 말하즈미, 박준형, 전재호, 파레디 묵람, 명훈

초록

The most common benign salivary gland tumor is pleomorphic adenoma. It affects major and minor salivary glands. Minor salivary gland tumors constitute <20% of all salivary gland neoplasms. Most minor salivary gland tumors occur on the palate. We present the case of a patient with pleomorphic adenoma that developed at a rare intraoral location. This patient presented to the Department of Oral and Maxillofacial Surgery of Seoul National University Dental Hospital.

669 2017 41권 5호

치아종과 하악 영구 전치의 융합: 증례 보고

저자 오성동, 이제우, 라지영

초록

The odontoma is a hamartomatous lesion consisting of enamel, dentin, pul and cementum. They are observed in the form of a tooth or as a mass of agglomerated teeth. Most of these occur during the period of development of normal teeth and grow to some extent. The fused tooth was the developmental abnormality of the teeth and the hard tissues of the adjacent teeth were combined. In general, these two lesions are not related, but two problems can occur together with systemic or local causes in the morphological differentiation period. We report a case of a 6 - year - old boy who visited our clinic for the eruption of a calcified mass in the mouth. The patient was diagnosed by the fusion of a odontoma and a mandibular permanent anterior tooth. And then, fused odontoma was removed surgically and the mandibular permanent anterior was restored by using composite resin. Calcified material was diagnosed as a composite tooth. After 6 months, the permannant teeth was satisfactory eruption and did not show any pathological problems in periapical radiography.

668 2017 41권 5호

악하선에 발생한 다형선종: 증례 보고

저자 정승환, 김진수, 이승준, 박재억, 김창현

초록

Pleomorphic adenoma is the most common benign tumor of the salivary glands. About 80-90% of pleomorphic adenoma occurs in the parotid gland and about 5-10% of them occur in the submandibular gland and sublingual gland. The rest proportion comprises the minor salivary glands. The palate is the most common area, followed by the lips and the cheeks. Pleomorphic adenoma of the submandibular gland shows clinically a slow-growing, painless mass found on submandibular aspect. In this case report, we report a case of pleomorphic adenoma of the right submandibular gland in a 63-year old female patient who was referred from the department of neurosurgery, due to the heterogenous mass detected by computed tomography (CT) and magnetic resonance imaging (MRI)

667 2017 41권 5호

비스포스포네이트가 인간 치수 줄기세포의 조골세포로의 분화와 광물화에 미치는 영향

저자 오종식, 유미현, 김형준, 신상훈, 이재열

초록

In this study, we investigated the effect of bisphosphonate on the osteoblastic differentiation of human dental stem cells (hDPSCs). In the first experiment, we evaluated the effect of bisphosphonate on the differentiation of hDPSCs into osteoblasts by alkaline phosphatase staining after culturing hDPSCs. As a result, on day 13, the osteogenic differentiation of hDPSC was suppressed at 5 μM in clodronate and 2 μM in zolendronate. In NBP, osteogenic differentiation is more suppressed. In second experiment, cytotoxicity and proliferation test, the cell proliferation (examined by MTT assay) was more suppressed as the concentrations of zolendronate were larger than those of alendronate and clodronate. Western blotting, a third experiment, was found that AKT phosphorylation was inhibited in cell signaling proteins involved in cell proliferation inhibition and death by bisphosphonate concentration. In human dental stem cells, bisphosphonates inhibit osteoblast differentiation, and this phenomenon is clearly observed in NBPs (zolendronate), and it has been found that it is related to AKT phosphorylation of cell signaling proteins.

666 2017 41권 5호

미더덕 낭액에 있는 생리활성물질의 초기 특성연구

저자 안지영, 진덕희, 이석근

초록

Styela clava (SC), a sea squirt has a biphasic life cycle, showed the animal phase during larval life and the vegetable phase during adult life. The adult SC becomes fixed on hard surface and covered with thick cellulose membrane to protect itself from various physical and chemical damages in marine environment. Especially, adult SC forms a huge cystic space as a portion of digestive tract, filled with seawater containing various planktons. In the present study, it is hypothesized that SC can produce secretory materials, like saliva in mammals, to sterilize, to neutralize, and to digest the cystic fluid. First of all, the cyst fluid was examined for the antimicrobial property by bacteria killing assay (BKA) using E. coli, and it resulted that the cyst fluid showed relatively weak bactericidal effect. The cyst fluid was also examined for antioxidant property by DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2-azinobis-3-ethybenzthiazdine- 6-sulphonic acid) assay, and resulted that the cyst fluid showed strong antioxidant effect comparable to ascorbic acid. The antioxidant materials of cyst fluid were found both in cationic and anionic groups separated by ion exchange column using SP and Q beads, and they were also heat resistant. The strong antioxidant property seems to be originated from the abundant carotenoid materials in the cyst fluid of SC. However, the strong antioxidant materials of the cyst fluid may play a role for the essential antioxidant in the digestive tract of SC. Furthermore, the cyst fluid of SC was examined using SNU-1 cancer cells for its anticancer property. The flow cytometry analysis showed that both of cationic and anionic materials purified from the cyst fluid showed strong anticancer effect on SNU-1 cells. Taken together, the cyst fluid of SC showed weak antimicrobial, but strong antioxidant property and marked anticancer properties in vitro experiment. Therefore, it is presumed that SCs can neutralize the various free radicals of seawater and also protect themselves from carcinogenic impacts in aggressive marine environment by various bioactve substances of their cyst fluid.

665 2017 41권 4호

우측 이하선에서 발생한 다형선종유래 암종

저자 장성백, 김도형, 이성탁, 권대근, 신홍인, 최소영

초록

Carcinoma ex pleomorphic adenoma (Ca ex PA) is an uncommon malignant tumor. It is an aggressive salivary carcinoma, arising from a primary or recurrent benign pleomorphic adenoma (PA). The most common clinical presentation of Ca ex PA is a firm mass in the parotid gland. Here we report a case of Ca ex PA, arising from a recurrent benign PA in the right parotid gland, in a 70-year old female patient. The lesion was first diagnosed as a PA and a superficial parotidectomy was performed. Re-operation was performed for recurrent PA. The second recurrence was diagnosed as Ca ex PA.

664 2017 41권 4호

측인두간극에 발생한 신경초종: 증례보고

저자 문찬웅, 권지은, 김철환

초록

Neurilemmomas, also known as schwannomas, are typically benign, well-encapsulated, slow-growing tumors originating from Schwann cells which encompass peripheral motor and sensory nerves. Neurilemmomas in parapharyngeal space (PPS) are very rare, but they can occasionally originate from the last four cranial nerves and autonomic nerves. In this article, we report the rare case of a 47-year-old male presenting solitary neck swelling and hoarseness. After computed tomography and magnetic resonance imaging, we performed complete surgical excision by a transcervical approach under general anesthesia. In the histologic examination, Neurilemmoma was diagnosed. The patient did not complain of any specific complications, showed good prognosis without recurrence or pain up to date.

663 2017 41권 4호

이하선에 발생한 와르틴 종양: 증례 보고

저자 조정우, 정승환, 김진수, 박재억, 김창현

초록

Warthin tumor, also known as papillary cystadenoma lymphomatosum is a benign neoplasm which occurs mostly in the parotid gland. It is the second most common benign neoplasm of the parotid gland, following pleomorphic adenoma. In occasion, the size of neoplasm grows slowly, and there is no symptom, except swelling. To prevent the recurrence, some surgeons prefer superficial parotidectomy, but the others prefer local resection with minimal surrounding tissue due to its low recurrence rate. We present a case of Warthin tumor of 55-year-old male.

662 2017 41권 4호

다중 정량 PCR을 이용한 치수 감염 원인 병원성 세균의 동시 검출 및 신속 동정

저자 장우성, 김가연

초록

The purpose of this study is to develop the quantitative PCR(qPCR) assay that would enable the rapid identification and simultaneous detection of six different endodontic pathogenic bacteria in a single reaction. In this study, six pairs of primers for Treponema denticola, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Streptococcus mutans, and Staphylococcus aureus and two pairs of housekeeping genes were designed for a multiplex qPCR based on the SYBR Green method. The genomic DNA was extracted from reference strains and submitted to the qPCR reaction. The specificity of the amplified products was analyzed by melting curves. As a result, six distinct melting peaks were identified by the melting curve analysis and all of the target species were simultaneously discriminated. Therefore, the multiplex qPCR assay developed in this study can be used for rapid identification and detection of T. denticola, P. gingivalis, F. nucleatum, P. intermedia, S. mutans, and S. aureus at the same time. In combination with the melting curve analysis, the level of the target species and total bacterial load can be obtained.

661 2017 41권 4호

치주염 조직에서 발현이 증가하는 CTGF에 의한 파골세포 생존 증가

저자 한혜연, 박종철, 유미현, 배문경, 김형준

초록

Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.

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