아가로즈-셀룰로오스 하이브리드 신소재의 물리화학적 특성과 의학및 생활 보건의 적용
In order to develop a protective carrier scaffolder for the external usage of medical and hygienic materials, three essentialprotective elements existing in nature, i.e., algin, cellulose, and calcium phosphate apatite, were investigated.The algin is a main skeletal component of sea weeds, the cellulose is of vegetables, and the calcium phosphate apatite isof vertebral animals. In the present study we select the agarose which is a derivative from algin, the cellulose fiber obtainedfrom skin of sea squirt, calcium oxide purified from shell powder, and tricalcium phosphate apatite purchasedcommercially. Consequently, the agarose-cellulose hybrid was made by the hydrogen bonds intermediating the calciumphosphate apatite between agarose and cellulose molecules. As the calcium phosphate apatite is formed by the additionof calcium hydroxide into tricalcium phosphate solution, we used calcium oxide to accelerate the hybridization betweenthe agarose and calcium phosphate apatite and also between the cellulose and calcium phosphate apatite. In the phasecontrast microscopic observation the agarose-cellulose hybrid showed more compact matrix structure than the mixture ofagarose and cellulose. The agarose-cellulose hybrid showed increased storage modulus but decreased loss modulus inRheometer test compared to those of the other materials tested in this study, representing that the agarose-cellulosehybrid has the highest elasticity among them and similar water capacity to agarose. The agarose-cellulose hybrid showedthe strongest antimicrobial effect in bacteria killing assay than the other materials, and also it showed a potent bloodclotting effect but no immunological hypersensitivity on the human skin. From the above results we presumed that thenobel material, agarose-cellulose hybrid, is a compact scaffolding matrix which has proper elasticity, high capacity tohold substrates, and antimicrobial and blood clotting property potent enough to carry the bio-medical and hygienic materialsfor external treatment safely.